Dobbed in weed-growing parents

[Madness]

Do you put on full PPE when you lube your chain?

Ed doesn't ride or own a bike. He claims it's his poor health that caused him to end his illustrious riding career but I reckon he's just frightened of riding when impaired by pharmaceuticals, despite it not being against the law for him to do so.

[Edbear]

Ed doesn't ride or own a bike. He claims it's his poor health that caused him to end his illustrious riding career but I reckon he's just frightened of riding when impaired by pharmaceuticals, despite it not being against the law for him to do so.

Ahuh... The truth is that following my acident and subsequent fusion, the surgeon warned that I had two dodgy vertebrae left, the L4, which is weak and the L5. He said if I damaged those I would be a paraplegic and there would little they could do, so said not to ride anymore.

Were it only me, I would still ride anyway, as I have never crashed a bike, but having said that I am well aware of the vulnerability. I smashed my back in a van at 45km/h.

But having spent a year or so in a wheelchair, I have no desire to repeat the experience and my wife and kids are paranoid that I might end up back in one. It's no fun at all. So in deference to them, I have agreed, under protest and with that gutted feeling every day, that I will not ride.

[Katman]

So in deference to them, I have agreed, under protest and with that gutted feeling every day, that I will not ride.

[Edbear]

You don't get to be an old dog without learning a few tricks.
Shorai Powersports batteries are very trick!

[Edbear]

But you would say that, wouldn't you?

Something's not right with the site, my answer didn't register.

[Madness]

...with that gutted feeling every day.

You don't suppose by now that this is more likely just another Tramadol side-effect? You're right about life as a junkie though, it looks like no fun at all from what I can see.

[Edbear]

You don't suppose by now that this is more likely just another Tramadol side-effect? You're right about life as a junkie though, it looks like no fun at all from what I can see.

Trust you to get everything backwards. Nothing whatsoever to do with drugs or meds.

But you like to be wrong as long as you can poke the borax, eh?

[Madness]

...borax.

What do you do with that, snort it?

[Akzle]

sorry im late to the party..

As I have pointed out many times, Tramadol is a drug that many cannot take but others can with few, if any, side effects. This is true for many types of drug as people have different reactions to the same medication.

like.....cannabis?

What is sad, here,. is that so many of you seem to be unable to function, or have any kind of fun without recreational drugs to alter your mind and mood. Says a lot about your life, or lack of...

according to whom?

Ah, but as I said, not everyone reacts the same way and for me I had no noticeable side effects... Even cutting down by more than half hasn't been too much of a problem. I tried cold-turkey, but too much pain, so slowed it down and increased Paracetamol. Still more pain, but manageable.

because paracetamol is good for you
(you fucking idiot)
please, please, Ed, double your dose af paracetamol.

"Total ignorance?" The only thing I haven't done is smoked it.

so yes. pretty much total ignorance. having consumed both cannabis and tramadol (and pretty much everything else under the sun) i can safely say: you're an ignorant cunt.

I belkieve in knowing what I'm talking about, so have done a lot of research into the current studies and research on cannabis and what they are developing from it and it's potential. I keep up to date on it. I doubt many here do.

and has this research lead you to the many and varied health benefits of cannabis, such as anti-seizure, anti-emeitic, analgesic, the reduction of intra-ocular pressure, etc, etc, et-fucking-cetera.

or... not?

Tramadol is an approved medical drug for pain relief and has been around for about 40 years or so. No comparison.

and thalidomide was approved for morning sickness for years, too.

i'm guessing your mum took full advantage of that approval... based on... you.

What you fail to understand, is that I am just finding it amusing to hear arguments from those who just want to get stoned.

oh no, ed, the failure is entirely yours. if i want to smoke cannabis, crack, meth, pcp, salvia, datura, tobacco... it wont be "the rules" that stop me. in fact, it want be anything. i'll do that shit.
and pity the cunt that tries to enforcre government policy against me.

but that's all irrelevant waffle (funny.. how that now you're here........)
becouse there are about fifty arguments FOR cannabis, and yet the only ones you can muster against it are: "i'm scared" and; "it's illegal"

well done. fuckwit.

Getting stoned is a waste of time.

according to whom?
and what time?
and whose time?
has "your" time personally been wasted by "getting stoned"?
no? so how about shutthefuckupyoudrongocunt

People do stupid things while under the influence of mind-altering drugs, too.

people do stupid shit stone-cold-sober.
what the fuck is your point?
i mean hell. you bother posting here, which can be considered both "a waste of time" (see above) and "stupid shit" (see: everything you post)

True! But for me, I'd rather keep my faculties intact.

i'd say we're a bit past that, ehh.

Fogging up my brain with drugs and/or alcohol, reducing my physical abilities, (and sensibilities), is not for me.

...and a bit too late for that, ehh.

If Tramadol had adverse effects, I would have gone onto something else years ago.

that thing. about biased perspective... observing from within the foggy drug induced haze... i'm sure most drunk cunts in town think it's a fucking riot to piss their name on an alley wall... until they're met by a sober opinion.

But the same could be said about those who choose to inhale the smoke from a burnout.

...or anyone who lives in a city... with all that *actually carcinogenic* diesel exhaust.

The only way is to lobby for a law change, and so far, TPTB have decided it's not going to change.

yes, and some of us grown-ups don't go looking to someone else to tell us what we can and can't do.
it's not "the only way".
i smoke the green, and (as above) pity the cunt that tries to enforce governmont policy against me.

The issue from their perspective, is that the drug, like alcohol, does cause unwanted side effects, esp. in driving and operating machinery, as also in many professions requiring alertness.

really. all that extensive research you've done, and you're comfortable posting THAT.

i guess that shows just how "extensive" your "research" has been.
fuckwit.

So how do they account for that in law? Alcohol is easier to police than cannabis being much more obvious in its effects.

uhhh.... EGG-FUCKING-SACTLY.

you. fucking. idiot.


how about, instead of some arbitrary measurable physiological effect, they do something radical... like, oh, i don't know, an actual IMPAIRMENT test....


all of this is rhetorical, ed. i don't want to hear from you, because you're too fucking stupid, i just had to post all this shit, so as your stupidity didn't go unrefuted.

[bogan]

I tried cold-turkey, but too much pain, so slowed it down and increased Paracetamol. Still more pain, but manageable.

You gotta be careful with that shit too, it'll fuck up your guts. Being reliant on drugs is pretty much a bad thing whatever their type, booze, cannabis, paracetamol, tramadol...

[bogan]

If Tramadol had adverse effects, I would have gone onto something else years ago.

Doesn't seem like many at all does it...

Contraindications
Tramadol hydrochloride tablets should not be administered to patients who have previously demonstrated hypersensitivity to tramadol, any other component of this product or opioids. Tramadol hydrochloride is contraindicated in any situation where opioids are contraindicated, including acute intoxication with any of the following: alcohol, hypnotics, narcotics, centrally acting analgesics, opioids or psychotropic drugs. Tramadol may worsen central nervous system and respiratory depression in these patients.

Warnings
Seizure Risk
Seizures have been reported in patients receiving tramadol hydrochloride tablets within the recommended dosage range. Spontaneous post-marketing reports indicate that seizure risk is increased with doses of tramadol hydrochloride tablets above the recommended range. Concomitant use of tramadol hydrochloride tablets increases the seizure risk in patients taking:

•
Selective serotonin reuptake inhibitors (SSRI antidepressants or anorectics),
•
Tricyclic antidepressants (TCAs), and other tricyclic compounds (e.g., cyclobenzaprine, promethazine, etc.), or
•
Other opioids.
Administration of tramadol hydrochloride tablets may enhance the seizure risk in patients taking:

•
MAO inhibitors (see also WARNINGS - Use with MAO inhibitors, and Serotonin Re-Uptake Inhibitors)
•
Neuroleptics, or
•
Other drugs that reduce the seizure threshold.
Risk of convulsions may also increase in patients with epilepsy, those with a history of seizures, or in patients with a recognized risk for seizure (such as head trauma, metabolic disorders, alcohol and drug withdrawal, CNS infections). In tramadol hydrochloride tablets overdose, naloxone administration may increase the risk of seizure.

Suicide Risk
Do not prescribe tramadol hydrochloride tablets for patients who are suicidal or addiction-prone.

Prescribe tramadol hydrochloride tablets with caution for patients who are taking tranquilizers or antidepressant drug and patients who use alcohol in excess and who suffer from emotional disturbance or depression.

The judicious prescribing of tramadol is essential to the safe use of this drug. With patients who are depressed or suicidal, consideration should be given to the use of non-narcotic analgesics.

Tramadol-related deaths have occurred in patients with previous histories of emotional disturbances or suicidal ideation or attempts as well as histories of misuse of tranquilizers, alcohol, and other CNS-active drugs (see WARNINGS, Risk of Overdosage).

Serotonin Syndrome Risk
The development of a potentially life-threatening serotonin syndrome may occur with the use of tramadol products, including tramadol hydrochloride tablets, particularly with concomitant use of serotonergic drugs such as SSRIs, SNRIs, TCAs, MAOIs, and triptans, with drugs which impair metabolism of serotonin (including MAOIs), and with drugs which impair metabolism of tramadol (CYP2D6 and CYP3A4 inhibitors). This may occur within the recommended dose (see CLINICAL PHARMACOLOGY, Pharmacokinetics).

Serotonin syndrome may include mental-status changes (e.g., agitation, hallucinations, coma), autonomic instability (e.g., tachycardia, labile blood pressure, hyperthermia), neuromuscular aberrations (e.g., hyperreflexia, incoordination) and/or gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea).

Anaphylactoid Reactions
Serious and rarely fatal anaphylactoid reactions have been reported in patients receiving therapy with tramadol hydrochloride tablets. When these events do occur it is often following the first dose. Other reported allergic reactions include pruritus, hives, bronchospasm, angioedema, toxic epidermal necrolysis and Stevens Johnson syndrome. Patients with a history of anaphylactoid reactions to codeine and other opioids may be at increased risk and therefore should not receive tramadol hydrochloride tablets (see CONTRAINDICATIONS).

Respiratory Depression
Administer tramadol hydrochloride tablets cautiously in patients at risk for respiratory depression. In these patients alternative non-opioid analgesics should be considered. When large doses of tramadol hydrochloride tablets are administered with anesthetic medications or alcohol, respiratory depression may result. Respiratory depression should be treated as an overdose. If naloxone is to be administered, use cautiously because it may precipitate seizures (see WARNINGS, Seizure Risk and OVERDOSAGE ).

Interaction with Central Nervous System (CNS) Depressants
Tramadol should be used with caution and in reduced dosages when administered to patients receiving CNS depressants such as alcohol, opioids, anesthetic agents, narcotics, phenothiazines, tranquilizers or sedative hypnotics. Tramadol increases the risk of CNS and respiratory depression in these patients.

Interactions with Alcohol and Drugs of Abuse
Tramadol may be expected to have additive effects when used in conjunction with alcohol, other opioids, or illicit drugs that cause central nervous system depression.

Increased Intracranial Pressure or Head Trauma
Tramadol hydrochloride tablets should be used with caution in patients with increased intracranial pressure or head injury. The respiratory depressant effects of opioids include carbon dioxide retention and secondary elevation of cerebrospinal fluid pressure, and may be markedly exaggerated in these patients. Additionally, pupillary changes (miosis) from tramadol may obscure the existence, extent, or course of intracranial pathology. Clinicians should also maintain a high index of suspicion for adverse drug reaction when evaluating altered mental status in these patients if they are receiving tramadol hydrochloride tablets. (See WARNINGS, Respiratory Depression)

Use in Ambulatory Patients
Tramadol may impair the mental and or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery. The patients using this drug should be cautioned accordingly.

Use with MAO Inhibitors and serotonin re-uptake inhibitors
Use tramadol hydrochloride tablets with great caution in patients taking monoamine oxidase inhibitors. Animal studies have shown increased deaths with combined administration. Concomitant use of tramadol hydrochloride tablets with MAO inhibitors or SSRI's increases the risk of adverse events, including seizure and serotonin syndrome.

Misuse, Abuse and Diversion
Tramadol has mu-opioid agonist activity. Tramadol hydrochloride tablets can be sought by drug abusers and people with addiction disorders and may be subject to criminal diversion. The possibility of illegal or illicit use should be considered when prescribing or dispensing Tramadol hydrochloride tablets in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse, or diversion. Misuse or abuse poses a significant risk to the abuser that could result in overdose and death (see DRUG ABUSE AND DEPENDENCE and OVERDOSAGE).

Concerns about abuse, addiction, and diversion should not prevent the proper management of pain. The development of addiction to opioid analgesics in properly managed patients with pain has been reported to be rare. However, data are not available to establish the true incidence of addiction in chronic pain patients.

Risk of Overdosage
Patients taking tramadol should be warned not to exceed the dose recommended by their physician. Tramadol products in excessive doses, either alone or in combination with other CNS depressants, including alcohol, are a cause of drug-related deaths. Patients should be cautioned about the concomitant use of tramadol products and alcohol because of potentially serious CNS additive effects of these agents. Because of its added depressant effects, tramadol should be prescribed with caution for those patients whose medical condition requires the concomitant administration of sedatives, tranquilizers, muscle relaxants, antidepressants, or other CNS depressant drugs. Patients should be advised of the additive depressant effects of these combinations.

Serious potential consequences of overdosage with tramadol hydrochloride tablets are central nervous system depression, respiratory depression and death. Some deaths have occurred as a consequence of the accidental ingestion of excessive quantities of tramadol alone or in combination with other drugs. In treating an overdose, primary attention should be given to maintaining adequate ventilation along with general supportive treatment (see OVERDOSAGE).

Withdrawal
Withdrawal symptoms may occur if tramadol hydrochloride tablets are discontinued abruptly. (See also DRUG ABUSE and DEPENDENCE) Reported symptoms have included anxiety, sweating, insomnia, rigors, pain, nausea, tremors, diarrhea, upper respiratory symptoms, piloerection, and rarely hallucinations. Other symptoms that have been reported less frequently with tramadol hydrochloride tablets discontinuation include panic attacks, severe anxiety, and paresthesias. Clinical experience suggests that withdrawal symptoms may be avoided by tapering tramadol hydrochloride tablets at the time of discontinuation.

Precautions
Acute Abdominal Conditions
The administration of tramadol hydrochloride tablets may complicate the clinical assessment of patients with acute abdominal conditions.

Use in Renal and Hepatic Disease
Impaired renal function results in a decreased rate and extent of excretion of tramadol and its active metabolite, M1. In patients with creatinine clearances of less than 30 mL/min, dosing reduction is recommended (see DOSAGE AND ADMINISTRATION).

Metabolism of tramadol and M1 is reduced in patients with advanced cirrhosis of the liver. In cirrhotic patients, dosing reduction is recommended (see DOSAGE AND ADMINISTRATION).

With the prolonged half-life in these conditions, achievement of steady-state is delayed, so that it may take several days for elevated plasma concentrations to develop.

Information for Patients
•
Patients should be informed that tramadol hydrochloride tablets may cause seizures and/or serotonin syndrome with concomitant use of serotonergic agents (including SSRIs, SNRIs, and triptans) or drugs that significantly reduce the metabolic clearance of tramadol.
•
Tramadol hydrochloride tablets may impair mental or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery.
•
Tramadol hydrochloride tablets should not be taken with alcohol containing beverages.
•
Tramadol hydrochloride tablets should be used with caution when taking medications such as tranquilizers, hypnotics or other opiate containing analgesics.
•
The patient should be instructed to inform the physician if they are pregnant, think they might become pregnant, or are trying to become pregnant (see PRECAUTIONS: Labor and Delivery).
•
The patient should understand the single-dose and 24-hour dose limit and the time interval between doses, since exceeding these recommendations can result in respiratory depression, seizures and death.
Drug Interactions
CYP2D6 and CYP3A4 Inhibitors
Concomitant administration of CYP2D6 and/or CYP3A4 inhibitors (see CLINICAL PHARMACOLOGY, Pharmacokinetics), such as quinidine, fluoxetine, paroxetine and amitriptyline (CYP2D6 inhibitors), and ketoconazole and erythromycin (CYP3A4 inhibitors), may reduce metabolic clearance of tramadol increasing the risk for serious adverse events including seizures and serotonin syndrome.

Serotonergic Drugs
There have been postmarketing reports of serotonin syndrome with use of tramadol and SSRIs/SNRIs or MAOIs and α2-adrenergic blockers. Caution is advised when tramadol hydrochloride tablet is coadministered with other drugs that may affect the serotonergic neurotransmitter systems, such as SSRIs, MAOIs, triptans, linezolid (an antibiotic which is a reversible non-selective MAOI), lithium, or St. John's Wort. If concomitant treatment of tramadol hydrochloride tablet with a drug affecting the serotonergic neurotransmitter system is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases (see WARNINGS, Serotonin Syndrome).

Triptans
Based on the mechanism of action of tramadol and the potential for serotonin syndrome, caution is advised when tramadol hydrochloride tablet is coadministered with a triptan. If concomitant treatment of tramadol hydrochloride tablet with a triptan is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases (see WARNINGS, Serotonin Syndrome).

Use with Carbamazepine
Patients taking carbamazepine may have a significantly reduced analgesic effect of tramadol hydrochloride tablets. Because carbamazepine increases tramadol metabolism and because of the seizure risk associated with tramadol, concomitant administration of tramadol hydrochloride tablets and carbamazepine is not recommended.

Use with Quinidine
Tramadol is metabolized to M1 by CYP2D6. Quinidine is a selective inhibitor of that isoenzyme, so that concomitant administration of quinidine and tramadol hydrochloride tablets results in increased concentrations of tramadol and reduced concentrations of M1. The clinical consequences of these findings are unknown. In vitro drug interaction studies in human liver microsomes indicate that tramadol has no effect on quinidine metabolism.

Potential for Other Drugs to Affect Tramadol
In vitro drug interaction studies in human liver microsomes indicate that concomitant administration with inhibitors of CYP2D6 such as fluoxetine, paroxetine, and amitriptyline could result in some inhibition of the metabolism of tramadol. Administration of CYP3A4 inhibitors, such as ketoconazole and erythromycin, or inducers, such as rifampin and St. John's Wort, with tramadol hydrochloride tablet may affect the metabolism of tramadol leading to altered tramadol exposure.

Potential for Tramadol to Affect Other Drugs
In vitro studies indicate that tramadol is unlikely to inhibit the CYP3A4-mediated metabolism of other drugs when tramadol is administered concomitantly at therapeutic doses. Tramadol does not appear to induce its own metabolism in humans, since observed maximal plasma concentrations after multiple oral doses are higher than expected based on single-dose data. Tramadol is a mild inducer of selected drug metabolism pathways measured in animals.

Use with Cimetidine
Concomitant administration of tramadol hydrochloride tablets with cimetidine does not result in clinically significant changes in tramadol pharmacokinetics. Therefore, no alteration of the tramadol hydrochloride tablets dosage regimen is recommended.

Use with Digoxin and Warfarin
Post-marketing surveillance has revealed rare reports of digoxin toxicity and alteration of warfarin effect, including elevation of prothrombin times.

Carcinogenesis, Mutagenesis, Impairment of Fertility
A slight, but statistically significant, increase in two common murine tumors, pulmonary and hepatic, was observed in a mouse carcinogenicity study, particularly in aged mice. Mice were dosed orally up to 30 mg/kg (90 mg/m2 or 0.36 times the maximum daily human dosage of 246 mg/ m2) for approximately two years, although the study was not done with the Maximum Tolerated Dose. This finding is not believed to suggest risk in humans. No such finding occurred in a rat carcinogenicity study (dosing orally up to 30 mg/kg, 180 mg/ m2, or 0.73 times the maximum daily human dosage).

Tramadol was not mutagenic in the following assays: Ames Salmonella microsomal activation test, CHO/HPRT mammalian cell assay, mouse lymphoma assay (in the absence of metabolic activation), dominant lethal mutation tests in mice, chromosome aberration test in Chinese hamsters, and bone marrow micronucleus tests in mice and Chinese hamsters. Weakly mutagenic results occurred in the presence of metabolic activation in the mouse lymphoma assay and micronucleus test in rats. Overall, the weight of evidence from these tests indicates that tramadol does not pose a genotoxic risk to humans.

No effects on fertility were observed for tramadol at oral dose levels up to 50 mg/kg (300 mg/ m2) in male rats and 75 mg/kg (450 mg/ m2) in female rats. These dosages are 1.2 and 1.8 times the maximum daily human dosage of 246 mg/ m2, respectively.

Pregnancy
Teratogenic Effects: Pregnancy Category C

Tramadol has been shown to be embryotoxic and fetotoxic in mice, (120 mg/kg or 360 mg/m2 ) rats (≥25 mg/kg or 150 mg/m2 ) and rabbits (≥75 mg/kg or 900 mg/m2 ) at maternally toxic doses, but was not teratogenic at these dose levels. These dosages on a mg/m2 basis are 1.4, ≥0.6, and ≥3.6 times the maximum daily human dosage (246 mg/m2) for mouse, rat and rabbit, respectively.

No drug-related teratogenic effects were observed in progeny of mice, (up to 140 mg/kg or 420 mg/m2 ), rats (up to 80 mg/kg or 480 mg/m2 ) or rabbits (up to 300 mg/kg or 3600 mg/m2 ) treated with tramadol by various routes. Embryo and fetal toxicity consisted primarily of decreased fetal weights, skeletal ossification and increased supernumerary ribs at maternally toxic dose levels. Transient delays in developmental or behavioral parameters were also seen in pups from rat dams allowed to deliver. Embryo and fetal lethality were 2 reported only in one rabbit study at 300 mg/kg (3600 mg/m2 ), a dose that would cause extreme maternal toxicity in the rabbit. The dosages listed for mouse, rat and rabbit are 1.7, 1.9 and 14.6 times the maximum daily human dosage (246 mg/m2 ), respectively.

Non-teratogenic Effects

Tramadol was evaluated in peri- and post-natal studies in rats. Progeny of dams receiving oral (gavage) dose levels of 50 mg/kg (300 mg/m2 or 1.2 times the maximum daily human tramadol dosage) or greater had decreased weights, and pup survival was decreased early in lactation at 80 mg/kg (480 mg/m2 or 1.9 and higher the maximum daily human dose).

There are no adequate and well-controlled studies in pregnant women. Tramadol hydrochloride tablets should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Neonatal seizures, neonatal withdrawal syndrome, fetal death and still birth have been reported during post-marketing.

Labor and Delivery
Tramadol hydrochloride tablets should not be used in pregnant women prior to or during labor unless the potential benefits out-weigh the risks. Safe use in pregnancy has not been established. Chronic use during pregnancy may lead to physical dependence and post-partum withdrawal symptoms in the newborn. (See DRUG ABUSE AND DEPENDENCE). Tramadol has been shown to cross the placenta. The mean ratio of serum tramadol in the umbilical veins compared to maternal veins was 0.83 for 40 women given tramadol during labor.

The effect of tramadol hydrochloride tablets, if any, on the later growth, development, and functional maturation of the child is unknown.

Nursing Mothers
Tramadol hydrochloride tablets are not recommended for obstetrical preoperative medication or for post- delivery analgesia in nursing mothers because its safety in infants and newborns has not been studied. Following a single IV 100 mg dose of tramadol, the cumulative excretion in breast milk within 16 hours post-dose was 100 µg of tramadol (0.1% of the maternal dose) and 27 µg of M1.

Pediatric Use
The safety and efficacy of tramadol hydrochloride tablets in patients under 16 years of age have not been established. The use of tramadol in the pediatric population is not recommended.

Geriatric Use
In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function and of concomitant disease or other drug therapy. In patients over 75 years of age, daily doses in excess of 300 mg are not recommended. (see CLINICAL PHARMACOLOGY and DOSAGE AND ADMINISTRATION).

A total of 455 elderly (65 years of age or older) subjects were exposed to tramadol hydrochloride tablets in controlled clinical trials. Of those, 145 subjects were 75 years of age and older.

In studies including geriatric patients, treatment-limiting adverse events were higher in subjects over 75 years of age compared to those under 65 years of age. Specifically, 30% of those over 75 years of age had gastrointestinal treatment-limiting adverse events compared to 17% of those under 65 years of age. Constipation resulted in discontinuation of treatment in 10% of those over 75.

Adverse Reactions
Tramadol hydrochloride tablets were administered to 550 patients during the double-blind or open-label extension periods in U.S. studies of chronic nonmalignant pain. Of these patients, 375 were 65 years old or older. Table 2 reports the cumulative incidence rate of adverse reactions by 7, 30, and 90 days for the most frequent reactions (5% or more by 7 days). The most frequently reported events were in the central nervous system and gastrointestinal system. Although the reactions listed in the table are felt to be probably related to tramadol hydrochloride tablets administration, the reported rates also include some events that may have been due to underlying disease or concomitant medication. The overall incidence rates of adverse experiences in these trials were similar for tramadol hydrochloride tablets and the active control groups, TYLENOL® with codeine #3 (acetaminophen 300 mg with codeine phosphate 30 mg), and aspirin 325 mg with codeine phosphate 30 mg, however, the rates of withdrawals due to adverse events appeared to be higher in the tramadol hydrochloride groups. [TYLENOL® is the registered trademark of McNeil Consumer Healthcare and TYLOX® is the registered trademark of RW Johnson].

Incidence 1% to less than 5%, possibly causally related: the following lists adverse reactions that occurred with an incidence of 1% to less than 5% in clinical trials, and for which the possibility of a causal relationship with tramadol hydrochloride tablets exists.

Body as a Whole: Malaise.

Cardiovascular: Vasodilation.

Central Nervous System: Anxiety, Confusion, Coordination disturbance, Euphoria, Miosis, Nervousness, Sleep disorder.

Gastrointestinal: Abdominal pain, Anorexia, Flatulence.

Musculoskeletal: Hypertonia.

Skin: Rash.

Special Senses: Visual disturbance.

Urogenital: Menopausal symptoms, Urinary frequency, Urinary retention.

Incidence less than 1%, possibly causally related: the following lists adverse reactions that occurred with an incidence of less than 1% in clinical trials and/or reported in post-marketing experience.

Body as a Whole: Accidental injury, Allergic reaction, Anaphylaxis, Death, Suicidal tendency, Weight loss, Serotonin syndrome (mental status change, hyperreflexia, fever, shivering, tremor, agitation, diaphoresis, seizures and coma).

Cardiovascular: Orthostatic hypotension, Syncope, Tachycardia.

Central Nervous System: Abnormal gait, Amnesia, Cognitive dysfunction, Depression, Difficulty in concentration, Hallucinations, Paresthesia, Seizure (see WARNINGS), Tremor.

Respiratory: Dyspnea.

Skin: Stevens-Johnson syndrome/Toxic epidermal necrolysis, Urticaria, Vesicles.

Special Senses: Dysgeusia.

Urogenital: Dysuria, Menstrual disorder.

Other adverse experiences, causal relationship unknown: A variety of other adverse events were reported infrequently in patients taking tramadol hydrochloride tablets during clinical trials and/or reported in post-marketing experience. A causal relationship between tramadol hydrochloride tablets and these events has not been determined. However, the most significant events are listed below as alerting information to the physician.

Cardiovascular: Abnormal ECG, Hypertension, Hypotension, Myocardial ischemia, Palpitations, Pulmonary edema, Pulmonary embolism.

Central Nervous System: Migraine, Speech disorders.

Gastrointestinal: Gastrointestinal bleeding, Hepatitis, Stomatitis, Liver failure.

Laboratory Abnormalities: Creatinine increase, Elevated liver enzymes, Hemoglobin decrease, Proteinuria.

Sensory: Cataracts, Deafness, Tinnitus.

[Katman]

But, but, but........

......it's government approved.

[Madness]

Come on guys, you know it isn't fair to engage in discussion with Ed after 4pm

[Katman]

Interesting poll result.

http://www.stuff.co.nz/national/poli...to-pot-smokers

[mashman]

Interesting poll result.

http://www.stuff.co.nz/national/poli...to-pot-smokers

Should do a Portugal and just get on with it.