Rather than issuing recommendations,
scientific journals publish articles where the authors might recommend for or against the use of a particular treatment. For example, The American Journal of Medicine previously published an editorial in which the authors recommend against the use of hydroxychloroquine for COVID-19 patients, which also doesn’t mean that it endorsed this recommendation.
Many articles and posts cite the article by McCullough et al. as a “study”, claiming “the study found that immediate use of hydroxychloroquine, while the patient was still at home, showed significant benefits”. This article focuses on early treatment strategies that can reduce the risk of hospitalization and death in ambulatory COVID-19 patients.
Given the lack of clinical trials and specific guidelines for the early treatment of COVID-19 patients, the authors propose several strategies and recommendations.
However, the publication by McCullough et al.
doesn’t provide new evidence on the effectiveness of hydroxychloroquine in COVID-19 patients, contrary to what many social media posts claim. “Studies” or “research articles” are publications that report newly collected research data and include specific sections describing the methods, results, and conclusions of the research. Instead, the article by McCullough et al. makes general recommendations for treating ambulatory COVID-19 patients based on previous evidence. In fact, the article’s summary highlights the lack of scientific evidence on the topic:
“In the absence of clinical trials and guidelines, with hospitalizations and mortality mounting, it is prudent to deploy treatment for COVID-19 based on pathophysiological principles”.
Therefore, the claim that the publication by McCullough et al. provides scientific evidence of the efficacy of hydroxychloroquine in COVID-19 patients is inaccurate.
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