You really are a guitarist ain't you?
People have been bike engines in cars and car engines in bikes (look at Guzzi's Vtwin - that was designed for a FIAT 500 originally) since, well internal combustion engines in vehicles. Load isn't an issue. You just X HP to get Y weight moving at Z velocity.
The biggest problem with putting a bike engine and transmission in a car body is the box has no reverse, and it is of course a sequential box. Setting up a foot clutch is not drama. It's just linkages after all, or even a cable if you want.
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