Jeff, this is one of those simple questions for which there is no simple answer.
To start with, I have zero information about the cylinder you have in mind, so I will have to assume that you want to derive it from a cylinder with angles as shown in my scavenging concept, below.
If you omit the C-port opposite the exhaust, I would leave the A-ports as they are, increase the B-ports' trailing position angle from 160° to 165°, increase their trailing direction angle from 132° to 137° and increase their axial angle from 10° to 15°, always assuming that there is sufficient material to do so.
If you want the best solution with only the A-ports, my first reaction would be: "You want to know how much 2 x 2 is, but you don't want the answer to be 4".
There is no way you can approach the scavenging quality of a 5-port layout with just 2 ports. You might increase the A-ports' trailing position angle from 100° to 140° and their trailing direction angle from 65° to 90°, always assuming that there is sufficient material, and decrease their axial angle from 25° to 20°.
But the lack of flow guidance in just two ultra-wide A-ports would not do any good. Besides, the piston ring would object to making the total port width of those 2 ports equal to the total port width of a 5-port scavenging layout.

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