I heard one of the hardest things on conrods and pistons is slamming the throttle shut suddenly from high rpm. Especially on V-twins with relatively bigger and heavier pistons. The piston coming up no longer has a air/fuel mix to compress and cushion itself against at the top of the stroke... instead there is now a vacuum in the combustion chamber and no cushion. This is when a conrod can stretch fractional more than usual and damage the piston.
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