Perhaps not the first corner...
But a good case in point was Hopkins in (I think) 2005 on the Suzuki at Sachsenring - He had a painkilling injection in his broken right foot and couldn't feel that he was standing on the brake lever mid corner which caused him to have a fantasmically high highside! And then, due the the NEW breaks in his foot, he couldn't get his ass off the track so they had to red flag it...
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