Drivers heading south on State Highway One are being urged to take care because about 2300 litres of automatic transmission fluid has been spilt on the road from Waiouru to Sanson.
Because of the fluid on the road a truck had jack-knifed near Ohingaiti, blocking the road, police said.
There had also been several non-injury crashes as a result of the spillage.
Inspector Marty Parker, of police central communications, said emergency services and a vehicle recovery unit were at the scene.
People planning to drive on the stretch of road should delay their travel plans.
Mr Parker said the vehicle that leaked the fluid had been found.
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