Hard cases are more convenient to use and more secure but in a slow speed crash or drop off road they can supposedly do bad things to your limbs. Soft panniers are more flexible in that they can be slid back or forward along the seat. Hard panniers tend to be perminantly mounted further back on the bike.
I did a 3 day trip with gear in a dry bag on the back of the seat and then did a ride with soft panniers slung over the seat and the panniers were far better with respect to weight distribution - much nicer to ride with and had more weight. Pics of my setup here although I dont use the top box much anymore (new rack and havent put base plate on yet).
Depends on the type of riding as much as anything. If mainly gravel and sealed roads then hard may be the way to go but if more off road then soft may be better.
Cheers R
"The ultimate result of shielding men from the effects of folly is to fill the world with fools." - Herbert Spencer, English Philosopher (1820-1903)
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